Quidel Molecular Direct C. difficile

For the qualitive detection and identification of toxigenic Clostridium difficle bacterial DNA using real time PCR

<70-minute turn-around time from sample to result.
3-step sample preparation
- No heat step
- No timed step
- No vortexing or centrifugation

Why Test?

Nucleic acid amplification tests can be as much as twice as sensitive as enzyme immunoassays.¹
Increasing rates of commmunity-acquired C. difficile.²
C. difficile infection (CDI) can range in severity from asymptomatic to life-threatening, especially among the elderly (most often nosocomially infected in hospitals, nursing homes or other medical institutions).³
Relapses of C. difficile have been reported in up to 20% of cases.⁴ Increases to 40% and 60% with subsequent recurrences.⁵
C. difficile infection often mimics some flu-like symptoms and can mimic disease flare in patients with inflammatory bowel disease associated colitis.⁶

ORDERING INFORMATION
Catalog	Kit Size/Volume	Description
M105	96 tests	Assay Kit
M207 (required for M105)	96 samples	Sample Prep Kit
M108	2 mL	Control Kit

Also available through Life Technologies.

¹Howell MD, Novack V, Grgurich P et al. Latrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. Arch. Intern. Med. May 2010:170 (9):784-90.
²Clabots CR, Johnson S, Olson MM, Peterson LR, Gering DN. Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infection. J. Infect Dis. Sept 1992:166 (3):561-7.
³Ryan KJ, CG (ed). Sherris Medical Microbiology (4th ed.) McGraw Hill. pp. 322-4.
⁴Kelly CP, LaMont JT. Clostridium difficile-more difficult than ever. N. Engl. J. Med. Oct 2008:359 (18): 1932-40.

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